Patients with malignant tumors positive for NTRK1, NTRK2 or NTRK3 gene fusion are Vitrakvi's indications.

GENE SCIENCE CO.,LTD. can provide patients with NTRK1, NTRK2 and NTRK3 gene fusion test.

When the NTRK gene fusion occurs on the chromosome, the partner fused with NTRK can mimic ligand-induced dimerization and undergo self-phosphorylation, that is, it can activate downstream pathways without accepting the ligand, promote cell proliferation and differentiation, and eventually lead to tumorigenesis.